Chitosan Nanocomposites Applied to the Field of Regenerative Medicine. A Systematic Review.
DOI:
https://doi.org/10.22517/23447214.23411Keywords:
Medicina Regenerativa, Nanocompuestos, Quitosano, Biomateriales, Biotecnología.Abstract
Chitosan is a biopolymer obtained from the chitin found in the exoskeleton of crustaceans, insects, arachnids and the cell wall of fungi. Recent research has confirmed the use of chitosan as a promising biomaterial due to its characteristics such as porous structure, the capacity of chemical modification, high affinity to macromolecules in vivo, among others. The aim of this systematic literature review was to evaluate the applications of chitosan as a biomaterial in regenerative medicine. A literature search was conducted between 2013-2018 in PubMed, Scopus, Web of Science and Embase databases. In this review, the “ToxRTool” (Toxicological data Reliability Assessment Tool) was used to assess the inherent quality or reliability of selected studies at the methodological level . The results showed that the chitosan nanocomposites are being studied mainly using in vitro methodologies (92.59%), diverse coupling components, and in multiple applications. However, the lack of methodological information concerning the use of controls for the experiments make reproducibility difficult and constrain the subsequent development of in vivo studies. The ToxRTool was found useful to identify eight studies (29.6%) as “Reliable without Restrictions” and 19 studies (70.4%) as “Reliable with restrictions”, indicating that more carefully studies concerning the toxicity of chitosan nanocomposites are required. Chitosan is a versatile biomaterial, which has allowed its incorporation into a wide variety of components, improving its biological, mechanical and physical properties, thus obtaining nanocomposites that are increasingly useful and effective for nanomedicine use.
Downloads
Downloads
-
Vistas(Views): 2526
- PDF (Español (España)) Descargas(Downloads): 1174
Published
How to Cite
Issue
Section
License
Copyrights
The journal is free open access. The papers are published under the Creative Commons Attribution / Attribution-NonCommercial-NoDerivatives 4.0 International - CC BY-NC-ND 4.0 license. For this reason, the author or authors of a manuscript accepted for publication will yield all the economic rights to the Universidad Tecnológica of Pereira free of charge, taking into account the following:
In the event that the submitted manuscript is accepted for publication, the authors must grant permission to the journal, in unlimited time, to reproduce, to edit, distribute, exhibit and publish anywhere, either by means printed, electronic, databases, repositories, optical discs, Internet or any other required medium. In all cases, the journal preserves the obligation to respect, the moral rights of the authors, contained in article 30 of Law 23 of 1982 of the Government Colombian.
The transferors using ASSIGNMENT OF PATRIMONIAL RIGHTS letter declare that all the material that is part of the article is entirely free of copyright. Therefore, the authors are responsible for any litigation or related claim to intellectual property rights. They exonerate of all responsibility to the Universidad Tecnológica of Pereira (publishing entity) and the Scientia et Technica journal. Likewise, the authors accept that the work presented will be distributed in free open access, safeguarding copyright under the Creative Commons Attribution / Recognition-NonCommercial-NoDerivatives 4.0 International - https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es license.