Un flavonoide de chromolaena perglabra induce muerte celular en celulas tumorales y proliferacion en celulas normales


Authors

  • Amparo Arango
  • Claudia Urueña
  • Oscar E. Rodriguez
  • Ruben E. Torrenegra
  • Susana Florentino G.

Abstract

Los siguientes compuestos son flavonides aislados de Chromolaena tacotana, CT1 y CT3, de Chromolaena bullata CB2, y de Chromolaena perglabara CP7. En el presente trabajo mostramos que el flavonoide CP7 (Chromolaena perglabara) afecta la morfología celular y disminuye la viabilidad celular en las siguientes líneas celulares humanas: K562, (eritroleucemia), A375, (melanoma) y una línea celular de melanoma murino Mel-Rel+. El análisis del ciclo celular demuestra que el flavonoide CP7 inhibe la proliferación celular, causa detención en G1 e induce apoptosis. La evaluación de la actividad biológica del flavonoide CP7 en células normales, muestra una actividad inmunoestimulatoria a través de un incremento en la proliferación de células mononucleares humanas estimuladas con PHA. Basados en estos resultados, proponemos que el CP7 es un flavonoide con alto potencial antitumoral e inmunoestimu lador. Los mecanísmos moleculares que regulan estas actividades están siendo estudiados en la actualidad.

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Published

2007-01-05

How to Cite

Arango, A., Urueña, C., Rodriguez, O. E., Torrenegra, R. E., & Florentino G., S. (2007). Un flavonoide de chromolaena perglabra induce muerte celular en celulas tumorales y proliferacion en celulas normales. Scientia Et Technica, 1(33). Retrieved from https://ojs2.utp.edu.co/index.php/revistaciencia/article/view/5805

Issue

Vol. 1 No. 33 (2007)

Section

Ciencias Básicas

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