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Predominance of the Luminal B molecular subtype in a group of women with infiltrating breast cancer from the coffee region of Colombia: Analysis by immunohistochemistry


Authors

  • Manuel Villegas-Jaramillo IPS interconsultas
  • Juan Paulo Preciado-Mosos IPS Virrey Solís
  • Andrés Felipe Mejía-Jiménez
  • Sebastián Chica-Gómez Unión de Cirujanos, Manizales
  • Édgar Fernando Pérez-Gaviria E.S.E. Hospital San Félix
  • Juliana Pava-De Los Ríos Universidad de Manizales
  • Alex Enrique Pava-Ripoll Universidad de Caldas
  • Paula Andrea Toro-Castaño Cleveland Clinic
  • Camilo Celis-Montoya E.S.E. Hospital San Camilo – Buenavista

DOI:

https://doi.org/10.22517/25395203.25015

Keywords:

Breast Cancer, Immunohistochemistry, Prognosis

Abstract

Breast cancer is the most common cancer in women and constitutes a public health problem due to its high rates of morbidity and mortality. Diagnosis is made through routine histopathology studies that are complemented by expression studies of hormone receptors (Estrogen and Progesterone Receptors), human epidermal growth factor 2 (HER2) and cell proliferation index (Ki67) for their subtyping into molecular groups (Luminal A, Luminal B, Her2 and triple negative), which have different prognostic and therapeutic implications. Globally, a high prevalence of the Luminal A subtype has been reported, predominantly in North America, Europe, and some Latin American countries; however, the reports in the Colombian population are heterogeneous. The objective of this research is to establish an incidence profile of these molecular subtypes in a population of the coffee region in Colombia. In retrospect, samples of 377 patients with a diagnosis of infiltrating breast cancer were analyzed, between the years 2015 and 2018. The histological diagnoses included: NOS infiltrating ductal carcinomas (339 cases; 89.9 %), infiltrating lobular (23 cases; 6.1%), infiltrating mucinous (6 cases; 1.5%), infiltrating papillary (1 case; 0.2%) and mixed patterns: ductal - lobular (3 cases; 0.7%) and ductal with mucinous component (5 cases; 1.3%), of which 56.2% (212 cases) correspond to luminal B, 22.2% (84 cases) to Luminal A, 14.8% (56 cases) to triple negative and 6.6% (25 cases) to HER2. These findings contrast with the prevalence reported worldwide. Therefore, in the population of the Colombian coffee region, this predominance of the luminal pattern B should be considered when establishing prognosis and treatment from medical staff.

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Author Biographies

Manuel Villegas-Jaramillo, IPS interconsultas

Médico. 

Juan Paulo Preciado-Mosos, IPS Virrey Solís

Médico.

 

Andrés Felipe Mejía-Jiménez

Médico.

Sebastián Chica-Gómez, Unión de Cirujanos, Manizales

Médico.

Édgar Fernando Pérez-Gaviria, E.S.E. Hospital San Félix

Médico.

Juliana Pava-De Los Ríos, Universidad de Manizales

Médica.

Alex Enrique Pava-Ripoll, Universidad de Caldas

Médico y Cirujano.

Especialista en patología.

Paula Andrea Toro-Castaño, Cleveland Clinic

Médica y Cirujana.

Especialista en patología anatómica y clínica.

Magíster en genética médica.

Camilo Celis-Montoya, E.S.E. Hospital San Camilo – Buenavista

Médico.

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Published

2022-10-30

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How to Cite

Villegas-Jaramillo, M., Preciado-Mosos, J. P. ., Mejía-Jiménez, A. F., Chica-Gómez, S., Pérez-Gaviria, Édgar F., Pava-De Los Ríos, J., Pava-Ripoll, A. E., Toro-Castaño, P. A., & Celis-Montoya, C. . (2022). Predominance of the Luminal B molecular subtype in a group of women with infiltrating breast cancer from the coffee region of Colombia: Analysis by immunohistochemistry. Revista Médica De Risaralda, 28(2). https://doi.org/10.22517/25395203.25015

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Original Article