Risk factors for coronary artery disease. New vision in mendelian randomization studies


Authors

  • Esperanza Pinzon Rozo Estudiante - Pregrado
  • Sheyla Alexandra Rodríguez Real
  • José Daniel Toledo Arenas
  • Michael Alexander Vallejo Urrego

DOI:

https://doi.org/10.22517/25395203.25469

Keywords:

Primary Prevention, Coronary Artery Disease, Coronary Disease, Mendelian Randomization Analysis

Abstract

Objective: To compile information on risk factors for coronary artery disease in the adult population evidenced by Mendelian randomization studies..

Methods: A search was carried out from the user of the Nueva Granada Military University in the databases of PubMed, EMBASE and BIREME and a narrative review of the literature was carried out in accordance with the recommendations of the scale for the Evaluation of Narrative Review Articles (SANRA).

Results: 757 articles were obtained, after the application of inclusion and exclusion criteria, 29 articles were chosen that investigated the association of apolipoprotein B, LDL cholesterol, triglycerides, total cholesterol, apolipoprotein C3, cholesterol ester transfer protein, HDL, omega 6, lipoprotein (a), obesity, hemoglobin A1C, type 2 diabetes mellitus, fasting glucose, smoking initiation, blood pressure, serum parathyroid hormone, serum phosphate levels, non-alcoholic fatty liver disease, polycystic ovary syndrome , sex hormone-binding globulin, testosterone, circulating phylloquinone, inactive matrix protein gla, circulating dietary-derived antioxidants, glycine, homocysteine, uric acid, inflammatory markers, hemoglobin, hematocrit, and red blood cell count, with coronary artery disease.

Conclusion: This review suggests new studies with Colombian genetic information to support the risk factors presented here, considering that none of the studies evaluated used Latin American genetic information, which may limit the extrapolation of the results.

Downloads

Download data is not yet available.

References

Achury Saldaña D, Castaño Riaño H, Gómez Rubiano L, Guevara Rodríguez N. Calidad de vida de los cuidadores de pacientes con enfermedades crónicas con parcial dependencia. Investigacion en enfermeria imagen y desarrollo. 2011;13(1):27–46.

Organización Panamericana de la Salud. Día Mundial del Corazón: Enfermedades cardiovasculares causan 1,9 millones de muertes al año en las Américas [Internet]. 2021 [Consultado 03 Feb 2023]. Disponible en: https://www3.paho.org/hq/index.php?option=com_content&view=article&id=7252:2012-world-heart-day-cardiovascular-diseases-cause-1-9-million-deaths-year-americas&Itemid=0&lang=es#gsc.tab=0

Organización Panamericana de la Salud. Las enfermedades del corazón siguen siendo la principal causa de muerte en las Américas [Internet]. 2021[Consultado 03 Feb 2023]. Disponible en: https://www.paho.org/es/noticias/29-9-2021-enfermedades-corazon-siguen-siendo-principal-causa-muerte-americas

Organización Panamericana de la Salud. ASSA2030 - Objetivo 9: Enfermedades no transmisibles [Internet] 2021 [Consultado 03 Feb 2023]. Disponible en: https://www.paho.org/es/assa2030-objetivo-9

Ministerio de salud y protección social-Colombia. Resolución número 1035 de 2022 [Internet]. 2022. [Consultado 03 Feb 2023]. Disponible en: https://www.minsalud.gov.co/Normatividad_Nuevo/Resoluci%c3%b3n%20No.%201035%20de%202022.pdf

SCC. Boletín No. 132 – SCC [Internet]. 2019[Consultado 03 Feb 2023]. Disponible en: https://scc.org.co/boletin-no-132/

Kisling LA, Das JM. Prevention Strategies. [Internet] 2023 [Consultado 03 Feb 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK537222/

Regmi M, Siccardi MA. Coronary Artery Disease Prevention. [Internet] 2023[Consultado 03 Feb 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK547760/

Rajasundaram S, Gill D. Tumour necrosis factor receptor 1 inhibition and cardiovascular disease: a cis-Mendelian randomization study. Eur J Prev Cardiol. 2023;30:i16–7.

Xu J, Li M, Gao Y, Liu M, Shi S, Shi J, et al. Using Mendelian randomization as the cornerstone for causal inference in epidemiology. Environ. Sci. Pollut. Res. 2022;29(4):5827–39.

Iturrieta-Zuazo I, Walter S. Aleatorización mendeliana: presente y futuro de los estudios epidemiológicos en cardiología. Rev Esp Cardiol.2015;68(2):87–91.

Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, et al. Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. PLoS Med. 2020;17(3):e1003062.

Zuber V, Gill D, Ala-Korpela M, Langenberg C, Butterworth A, Bottolo L, et al. High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease. Int J Epidemiol. 2021;50(3):893–901.

Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, et al. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nat Commun. 2021;12(1):6120.

Wang K, Shi X, Zhu Z, Hao X, Chen L, Cheng S, et al. Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations. Genome Med.2022;14(1).

Ference BA, Kastelein JJP, Ray KK, Ginsberg HN, Chapman MJ, Packard CJ, et al. Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease. JAMA. 2019;321(4):364–73.

Jansen SA, Huiskens B, Trompet S, Jukema Jw, Mooijaart SP, Willems van Dijk K, et al. Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization. Geroscience. 2022;44(3):1703–13.

Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, et al. Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease. J Am Coll Cardiol.2018;72(3):300–10.

Goyal S, Tanigawa Y, Zhang W, Chai JF, Almeida M, Sim X, et al. APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups. Lipids Health Dis. 2021;20(1):113.

Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP, et al. CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease. Circ Genom Precis Med. 2018;11(5):e002034.

Prats-Uribe A, Sayols-Baixeras S, Fernández-Sanlés A, Subirana I, Carreras-Torres R, Vilahur G, et al. High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study. Metabolism. 2020;112:154351.

Liao LZ, Li WD, Liu Y, Li JP, Zhuang XD, Liao XX. Exploring the causal pathway from omega-6 levels to coronary heart disease: A network Mendelian randomization study. Nutr Metab Cardiovasc Dis. 2020;30(2):233–40.

Park S, Lee S, Kim Y, Lee Y, Kang M, Kim K, et al. Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study. Nutrients. 2021;13(5).

Lamina C, Kronenberg F. Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis. JAMA Cardiol. 2019;4(6):575–9.

Zhang X, Lv WQ, Qiu B, Zhang LJ, Qin J, Tang FJ, et al. Assessing causal estimates of the association of obesity-related traits with coronary artery disease using a Mendelian randomization approach. Sci Rep.2018;8(1):7146.

Lv WQ, Zhang X, Fan K, Xia X, Zhang Q, Liu HM, et al. Genetically driven adiposity traits increase the risk of coronary artery disease independent of blood pressure, dyslipidaemia, glycaemic traits. European Journal of Human Genetics. 2018;26(10):1547–53.

Burgess S, Malik R, Liu B, Mason AM, Georgakis MK, Dichgans M, et al. Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus. Diabetologia. 2021;64(4):845–9.

Leong A, Chen J, Wheeler E, Hivert MF, Liu CT, Merino J, et al. Mendelian Randomization Analysis of Hemoglobin A(1c) as a Risk Factor for Coronary Artery Disease. Diabetes Care. 2019;42(7):1202–8.

Chen S, Yang F, Xu T, Wang Y, Zhang K, Fu G, et al. Smoking and coronary artery disease risk in patients with diabetes: A Mendelian randomization study. Front Immunol. 2023;14:891947.

Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, et al. Genetically predicted midlife blood pressure and coronary artery disease risk: Mendelian randomization analysis. J Am Heart Assoc.2020;9(14).

Melhus H, Michaëlsson K, Larsson SC. Serum Parathyroid Hormone and Risk of Coronary Artery Disease: Exploring Causality Using Mendelian Randomization. Journal of Clinical Endocrinology and Metabolism. 2019;104(11):5595–600.

Campos-Obando N, Kavousi M, Van Der Eerden B, Uitterlinden AG, Zillikens MC. Genetic evidence for a causal role of serum phosphate in coronary artery calcification: The Rotterdam study. Calcif Tissue Int. 2019;104:S25.

Ren Z, Simons PIHG, Wesselius A, Stehouwer CDA, Brouwers MCGJ. Relationship between NAFLD and coronary artery disease: A Mendelian randomization study. Hepatology. 2023;77(1):230–8.

Simons PIHG, Cornelissen MEB, Valkenburg O, Onland-Moret NC, van der Schouw YT, Stehouwer CDA, et al. Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study. Clin Endocrinol (Oxf). 2022;96(4):599–604.

Li Y, Si S, Hou L, Yuan T, Chen X, Liu C, et al. Causal effect of sex hormone-binding globulin and testosterone on coronary heart disease: A multivariable and network Mendelian randomization analysis. Int J Cardiol. 2021;339:179–84.

Zwakenberg SR, Burgess S, Sluijs I, Weiderpass E, Beulens JWJ, van der Schouw YT. Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk: A two-sample Mendelian Randomization study. Clin Nutr. 2020;39(4):1131–6.

Luo J, le Cessie S, van Heemst D, Noordam R. Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study. J Am Coll Cardiol. 2021;77(1):45–54.

Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, et al. Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease. J Am Heart Assoc. 2019;8(10):e011922.

Xu T, Chen S, Yang F, Wang Y, Zhang K, Fu G, et al. The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomization study. Acta Diabetol. 2021;58(3):301–7.

Zhao Q, Liu R, Chen H, Yang X, Dong J, Bai M. White blood cells and coronary heart disease: A mendelian randomization study. Front Genet. 2023;14.

Downloads

Published

2024-07-17

How to Cite

Pinzon Rozo, E., Rodríguez Real , S. A. ., Toledo Arenas, J. D. ., & Vallejo Urrego , M. A. (2024). Risk factors for coronary artery disease. New vision in mendelian randomization studies. Revista Médica De Risaralda, 30(1), 119–136. https://doi.org/10.22517/25395203.25469

Issue

Vol. 30 No. 1 (2024): Enero-Junio 2024

Section

Scoping Review

License

Cesión de derechos y tratamiento de datos

La aceptación de un artículo para su publicación en la Revista Médica de Risaralda implica la cesión de los derechos de impresión y reproducción, por cualquier forma y medio, del autor a favor de  Facultad de Ciencias de la Salud de la Universidad Tecnológica de Pereira. 1995-2018. Todos los derechos reservados ®

por parte de los autores para obtener el permiso de reproducción de sus contribuciones. La reproducción total o parcial de los trabajos aparecidos en la Revista Médica de Risaralda, debe hacerse citando la procedencia, en caso contrario, se viola los derechos reservados.

Asimismo, se entiende que los conceptos y opiniones expresados en cada trabajo son de la exclusiva responsabilidad del autor, sin responsabilizarse ni solidarizarse, necesariamente, ni la redacción, ni la editorial.

Es responsabilidad de los autores poder proporcionar a los lectores interesados copias de los datos en bruto, manuales de procedimiento, puntuaciones y, en general, material experimental relevante.

Asimismo, la Dirección de la revista garantiza el adecuado tratamiento de los datos de carácter personal